“Who’s That Girl” is the story of how people can create an impact in our lives, and how a single mistake can be life-altering. Anne Curtis is Bea, a wallflower, while Luis Manzano is John Eduque, a campus heartthrob who is Bea’s ultimate crush. John hardly takes notice of Bea. But one day at her lowest, John surprisingly gives Bea a pep talk. This becomes life-changing for her. Bea transforms into a beautiful and successful career woman and John remains to be her dream man. So when she reads his name in the obituary, Bea is shattered with grief and goes to the wake in hysterics to the shock of everyone. It turns out that the deceased is John Eduque Sr., John’s father. Realizing her mistake, Bea hurriedly leaves, unaware of the damage she has caused especially on the widow, played by Eugene Domingo. Thinking that Bea is the mistress of the deceased, Mrs. Eduque succumbs to depression. Seeing his mother’s misery, John looks for Bea to rectify the situation. But the revenge ploy backfires as he falls in love with her. Fearing his mother’s reaction becomes a dilemma.