They are everyday women who all live under a world where men rule business and women rule the office. In this comedy hit of the summer, the story begins with Paula, (Eugene Domingo) is the daughter-in-law of Nimfa (Gina Pareno), she is queen of fake designer bags she earns high earning a living and puts her children through private school, a life that her irresponsible and unemployed husband cannot provide. Then there is single mom, Ada (Jennylyn Mercado), a young woman who is a call center agent by night and student by day, working hard to provide for her young son. In the process, she neglects her son and put additional strain on her relationship with her mother, Sabel (Rio Locsin). Ada is also close friends with Tobz (Carlo Aquino) who is currently having issues with his girlfriend, Wendy (Cristine Reyes) also a busy woman who does not give him time nor pleasure and whose long life goal is become an actor. While pursuing this, she meets Rodney (Rafael Rosell), who is also an attorney to celebrity plastic surgeon, Dr. Cleo Carillo. One of her clients/friends, Marilou (Ruffa Guttierez), a beauty queen turned CEO upon the death of her husband, is also having problems with Amanda Dela Vega, her husband's daughter from another marriage and Amanda's daughter, Dara Dela Vega (Bianca King). Dara is a Berkley graduate who is eager to prove herself at her new job for a television show; she is struggling to manager her issues from home and her issues boss, Suzanne (Carmi Martin) who is also Marilou's best friend. Another story follows Theresa (Iza Calzado), a nurse for Dr. Carillo's husband and who, is content with her work but struggles to deal with her broken heart.

This story reflects the challenges of everyday woman, involving family, love, money and the community. The story is based on the hit Viva Films Comedy 25 years ago is the sequel to Ishmael Bernal's Blockbuster top grosser in the 80's.